Fig. 8

Comparison of final product titers measured from stirred tank cultivations during screening of optimal pH shift time and final value. The scatter plot illustrates the concentrations of illudin M at the time of maximum productivity. Dots are colored according to the pH evaluated, the labels indicate the pH value after the shift. Experiments where pH was shifted at 74 h reached the maximum titers at 168 h and all other experiments at 192 h. Illudin M titers were derived from cell free culture supernatant