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Fig. 11 | Microbial Cell Factories

Fig. 11

From: Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors

Fig. 11

Comparison of process kinetics from cultivations of 1.5 L (DASGIP) and 10 L (BBI) in stirred tank bioreactors. Legends marked with D illustrate process values from DASGIP cultivation and B from BBI cultivation. a Kinetics of OTR-CTR and product formation over the cultivation time. b Consumption of glucose and acetate over the cultivation time. Dashed curves illustrate the data from BBI cultivation and solid curves the DASGIP cultivation c, d Illustrate a comparison of the integrated OTR and CTR values (OT and CT) and the blue circle highlights the time for acetate feeding (96 h). e Comparison of tip speed. f Comparison of the approximated EDCF values calculated with energy dissipation circulation function. Stirring speed was increased from 150 min−1 to 200 min−1 at 48 h in the 10 L cultivation (e, f), which explains the step-wise increase of the values at that time point

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