Table 2 Examples of engineering probiotics in clinical trials
From: Engineered probiotics
Species | Engineered probiotic | Disease/function | Research facility | Stage | Result | ClinicalTrials.gov identifier |
|---|---|---|---|---|---|---|
E. coli | SYNB1934 SYNB1618 | Phenylketonuria | Synlogic | Phase 1 | – | NCT04984525 |
E. coli | SYNB1618 | Phenylketonuria | Synlogic | Phase 1/2a | – | NCT03516487 NCT04534842 |
E. coli | SYNB8802 | Enteric Hyperoxaluria | Synlogic | Phase 1 | – | NCT04629170 |
E. coli | SYNB1891 | Metastatic Solid Neoplasm and Lymphoma | Synlogic | Phase 1 | – | NCT04167137 |
E. coli | SYNB1020 | Cirrhosis and Hyperammonemia | Synlogic | Phase 1/2 | Terminated | NCT03447730 |
Bacteroides* | NB1000S | Enteric Hyperoxaluria | Novome | Phase 1/2a | – | NCT04909723 |
Lactococcus lactis | AG013 | Oral Mucositis | Oragenics/Precigen ActoBio | Phase 2 | Terminated | NCT03234465 |
Lactococcus lactis | AG019 | Type 1 diabetes | Precigen ActoBio | Phase 1/2 | – | NCT03751007 |
B. longum | bacTRL-IL-12 | Solid Tumours | Iqvia Pty Ltd | Phase 1 | – | NCT04025307 |