Fig. 10
From: AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus
The proposed model showing the regulation of AdpASn in central metabolism and acetate metabolism pathways. A Proposed model of the AdpASn-mediated regulatory network in S. albulus SNA. Solid lines indicate the direct regulation confirmed experimentally in this paper. Dashed lines indicate that bldA could affect the translation level of the UUA codon-containing gene adpASn. B The effects of AdpASn on metabolic network and ε-PL biosynthesis are displayed. The seven target genes of AdpASn are indicated in the simplified metabolic network, and the green, red and blue fonts or arrows stand for negative regulation, positive regulation and no regulation of AdpASn, respectively. The green dotted arrows mean these metabolic pathways may be negatively regulated because the transcription level change of the gene (DC74_334) encoding the isozyme of DC74_2409 is unknown