Fig. 1
taken from Co-enzyme A attached to the PPTase enzyme, enabling the conformational changes to the ACP-domain, as seen in C where the inactive apo-form is transformed into the active holo-form
Illustration of the iterative function of a type 1 fungal PKS and interaction with a PPTase. A Modular representation of a type 1 fungal PKS containing multiple domains responsible for production of the first polyketide intermediate. B Shows the 4′-phosphopantetheinyl moeity