Table 1 Summary of the top 20 reactions based on absolute differences in flux medians at 24Â h among the yeast strains, and their corresponding gene associations and metabolic subsystems. Reactions are listed according to absolute median differences starting with the largest
Genes (Short Name) | Gene Association | Reaction Names | GSMM Reaction Number | Metabolic Subsystem |
|---|---|---|---|---|
ARO9 | YHR137W | Tyrosine transaminase | r_2119 | Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway) |
ALT2 | YDR111C | L-Alanine:2-oxoglutarate aminotransferase | r_4226 | Alanine metabolism |
ACO2 | YJL200C | Citrate hydroxymutase | r_4262 | Citric Acid Cycle |
ADH5 ADH1 | YBR145W YOL086C | Alcohol dehydrogenase, (acetaldehyde to ethanol) | r_2115 | Glycolysis, Fatty acid degradation, Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway) |
GLO2 | YDR272W | Hydroxyacylglutathione hydrolase | r_0553 | Pyruvate metabolism |
GLO1 | YML004C | Lactoylglutathione lyase | r_0697 | Pyruvate metabolism |
HSP31 SNO4 HSP33 HSP32 | YDR533C YMR322C YOR391C YPL280W | (R)-lactate hydro-lyase | r_4236 | Other carbon metabolism |
PGK1 | YCR012W | Phosphoglycerate kinase | r_0892 | Glycolysis, Carbon metabolism |
TDH3 TDH1 TDH2 | YGR192C YJL052W YJR009C | Glyceraldehyde-3-phosphate dehydrogenase | r_0486 | Glycolysis, Gluconeogenesis, Carbon metabolism, Biosynthesis of secondary metabolites |
CDC19 PYK2 | YAL038W YOR347C | Pyruvate kinase | r_0962 | Pyruvate metabolism, Glycolysis, Purine metabolism, Carbon metabolism, |
GPM1 | YOR283W YKL152C | Phosphoglycerate mutase | r_0893 | Glycine, serine and threonine metabolism, Glycolysis, Carbon metabolism |
PDC6 PDC1 PDC5 | YGR087C YLR044C YLR134W | Pyruvate decarboxylase | r_0959 | Glycolysis, Gluconeogenesis, Biosynthesis of secondary metabolites (Ehrlich pathway) |
ADH2 | YMR303C | Alcohol dehydrogenase (ethanol to acetaldehyde) | r_0163 | Glycolysis, Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway), Fatty acid degradation |
GLK1 HXK1 HXK2 EMI2 | YLR446W YCL040W YFR053C YGL253W YDR516C | Hexokinase (D-glucose:ATP) | r_0534 | Glycolysis, Gluconeogenesis, Fructose and mannose metabolism, Galactose metabolism, Amino sugar and nucleotide sugar metabolism, Carbon metabolism, Biosynthesis of secondary metabolites |
AAT2 | YLR027C | Aspartate transaminase | r_0216 | Alanine, aspartate and glutamate metabolism, Tyrosine metabolism, Cysteine and methionine metabolism |
HOM2 | YDR158W | Aspartate-semialdehyde dehydrogenase | r_0219 | Glycine, serine and threonine metabolism, Cysteine and methionine metabolism |
HOM6 | YJR139C | Homoserine dehydrogenase (NADH) | r_0546 | Glycine, serine and threonine metabolism; Cysteine and methionine metabolism, Biosynthesis of secondary metabolites |
THI3 PDC6 PDC1 PDC5 | YDL080C YGR087C YLR044C YLR134W | 3-methyl-2-oxopentanoate decarboxylase | r_0064 | Glycolysis, Gluconeogenesis, Biosynthesis of secondary metabolites (Ehrlich pathway) |
GPD1 GPD2 | YDL022W YOL059W | Glycerol-3-phosphate dehydrogenase (NAD) | r_0491 | Glycerophospholipid metabolism, Biosynthesis of secondary metabolites |
GND1 GND2 | YGR256W YHR183W | Phosphogluconate dehydrogenase | r_0889 | Glutathione metabolism, Carbon metabolism, Biosynthesis of secondary metabolites |