Fig. 7
Effect of L-isoleucine supplement on FK506 production. a Effect of different concentrations of L-isoleucine on FK506 production in shake-flask culture. b FK506 production analyzed in a 15-L stirred-tank bioreactor with 8-L Fm1. Error bars show standard deviations of three independent experiments. The asterisks indicated the statistic significant differences. *P < 0.05; N, no significant difference