Fig. 6

The proposed relationships of amphotericin biosynthesis with relevant metabolic pathways in S. nodosus. The key metabolic pathways were marked by red, including central carbon metabolism, fatty acids metabolism, purine metabolism and one carbon pool by folate. EMP Embden–Meyerhof–Parnas pathway, TCA tricarboxylic acid cycle, Glu glucose, G6P glucose 6-phosphate, F6P fructose 6-phosphate, G3P glucose 3-phosphate, G2P glucose 2-phosphate, PEP phosphoenolpyruvate, Pyr pyruvate, CIT citrate, ISO-CIT iso-citrate, AKG α-ketoglutarate, SUC-CoA succiny-CoA, SUC succinate, FUM fumaric acid, MAL malic acid, OAA oxalacetic acid, Lac lactate, Ser serine, Gly glycine, Cys cysteine, Glu glutamic, Gsh glutathione, Asp aspartic, Dap diaminopimelate, Lys lysine, His histidine, THF tetrahydrofolic, Met methionine, SAM S-adenosine methionine, SAH S-adenosyl-l-homocysteine, PRPP 5-Phospho-alpha-d-ribose-1-diphosphate, PR-AMP phosphoribosyl-adenosine monophosphate, GAR glycinamide ribonucleotide, FGAR formyl-glycinamide ribonucleotide, FGAM formyl glycinamidine ribonucleotide, AIR 5-aminoimidazole ribonucleotide, AICAR 5-aminoimidazole-4-carboxamide ribonucleotide