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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48

Fig. 2

Comparative transcriptomics analysis of A. orientalis CPCC 200066 and NCPC 2-48. a NCPC 2-48's differentially expressed genes (DEGs) with greater than two-fold change (FC) and FDR ≤ 0.001 in expression compared to the CPCC 200066 at each time points. b Hierarchical clustering of DEGs for each time points. Only DEGs that showed in all pairwise were used to build this heatmap. Gradient color barcode at the right top indicates log2(fold change) value. Each row represents a gene and each column represents a pairwise. Genes with similar expression value are clustered both at row and column level. c Statistics of pathway enrichment of DEGs in 24 h’s pairwise. Ratio is the DEGs numbers annotated in this pathway term to all gene numbers annotated in this pathway term. Greater Ratio means greater intensiveness. Orange line is -log10(p-value). We just display the top 20 of enriched pathway terms. d The whole genome (top) and nvcm cluster (below) expression on transcriptome level for each sample. The samples from the three different time points (12 h, 24 h, 48 h) of the original strain CPCC 200066 were named B12, B24, and B48. The samples of high-yield strains NCPC 2–48 were named N12, N24 and N48

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Microbial Cell Factories

ISSN: 1475-2859

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