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Table 2 Design space, factors and responses including standard deviations from full factorial study comprising 11 + 3 additional bioreactor cultivations

From: Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

Name

P/V [W/m3]

Qs [gs/gx/h]

dO2 [%]

Mean pellet size [µm]

Mean C [−]

Mean vl [µm]

Mean qp [gP/gX/d]

LLL

370

0.017

5.0

150.7 ± 9.5

0.51 ± 0.02

31.5 ± 5.1

0.18 ± 0.12

HLL

2012

0.018

5.0

129.3 ± 4.5

0.88 ± 0.03

38.6 ± 3.0

0.19 ± 0.09

LHL

370

0.040

5.0

183.1 ± 9.3

0.52 ± 0.02

22.1 ± 9.8

0.02 ± 0.01

HHH1

1900

0.042

40.0

135.7 ± 9.0

0.61 ± 0.03

33.6 ± 3.1

0.41 ± 0.24

LLH

370

0.015

40.0

161.7 ± 9.0

0.48 ± 0.02

40.1 ± 4.2

0.29 ± 0.23

MMH

1535

0.038

40.0

136.5 ± 5.8

0.48 ± 0.01

33.1 ± 3.0

0.38 ± 0.17

LHH

370

0.045

40.0

142.3 ± 5.3

0.44 ± 0.03

28.9 ± 2.9

0.29 ± 0.17

HHH2

2700

0.049

40.0

128.7 ± 5.1

0.85 ± 0.02

31.7 ± 2.3

0.34 ± 0.21

CP1

1535

0.034

22.5

136.5 ± 8.0

0.49 ± 0.05

36.4 ± 3.1

0.44 ± 0.19

CP2

1535

0.033

22.5

136.1 ± 5.8

0.48 ± 0.02

33.3 ± 3.5

0.40 ± 0.16

CP3

1535

0.035

22.5

129.6 ± 4.5

0.49 ± 0.03

38.1 ± 3.0

0.48 ± 0.21

MHH

1113

0.054

40.0

128.0 ± 5.1

0.49 ± 0.02

28.0 ± 3.1

0.13 ± 0.09

MMM

1535

0.026

22.5

141.7 ± 6.9

0.50 ± 0.03

40.1 ± 4.2

0.29 ± 0.13

HHH3

3000

0.050

40.0

120.8 ± 5.1

0.88 ± 0.03

31.0 ± 3.2

0.30 ± 0.19