Fig. 2

LC–ESI–MS profiles of methanol extracts of Tripterygium wilfordii root and leaves. a Methanol extracts of root tissue (three biological replicates; dashed line) show a strong peak at 11.7 min with m/z of 451.2830 [M+H]+ corresponding to celastrol. The identity of the compound was confirmed using a celastrol standard (solid line). b Mass spectrum of celastrol eluting at 11.7 min. c Structure of celastrol