TLR-2 expression and dysregulated human Treg/Th17 phenotype in Aspergillus flavus infected patients of chronic rhinosinusitis with nasal polyposis

Table 2 Cytokine profile of CRSwNP cases and healthy controls after stimulation with antigen:

Cytokines	Antigen/stimulant	HC	p-value	NP	p-value	NPF	p-value	HC
IL-17 (pg/ml)	Unstimulated	7.49 ± 5.4	0.224	3.94 ± 2.16	0.07	6.57 ± 2.59	0.74	7.49 ± 5.4
	PHAM	272 ± 97.4	0.01	93.8 ± 92.31	0.39	129 ± 54.23	0.02	272 ± 97.4
	A. flavus	6.63 ± 3.06	0.013	16.37 ± 8.12	0.032	7.89 ± 4.83	0.61	6.63 ± 3.06
IL-10 (pg/ml)	Unstimulated	111.07 ± 86.7	0.029	458.8 ± 357.8	0.047	154 ± 32.1	0.26	111.07 ± 86.7
	PHAM	900.43 ± 283.64	0.079	508.25 ± 488.38	0.807	554.25 ± 146.58	0.02	900.43 ± 283.64
	A. flavus	23.00 ± 19.17	0.019	667.36 ± 536.4	0.025	930.83 ± 167.21	0.00	23.00 ± 19.17
IL-2 (pg/ml)	Unstimulated	48.02 ± 1.27	0.01	44.3 ± 0.67	0.081	45.5 ± 0.23	0.012	48.02 ± 1.27
	PHAM	47.03 ± 0.70	0.035	65.8 ± 18.39	0.06	50.1 ± 3.39	0.07	47.03 ± 0.70
	A. flavus	47.5 ± 1.7	0.23	46.34 ± 1.17	0.93	46.2 ± 1.29	0.23	47.5 ± 1.7
TGF-β (pg/ml)	Unstimulated	5796 ± 1236.64	0.027	3990 ± 964.1	0.012	8365 ± 2840.31	0.039	5796 ± 1236.6
	PHAM	5850 ± 1398.62	0.039	4016.25 ± 628.6	0.034	9885 ± 4975.68	0.107	5850 ± 1398.6
	A. flavus	6306 ± 2021	0.039	3603.75 ± 584.7	0.015	8890 ± 3590.87	0.172	6306 ± 2021

Data are expressed as mean ± SD and p ≤ 0.05 considered as significant
HC healthy controls, NP cases before treatment, NPF cases after treatment, pg/ml picogram/milliliter

ISSN: 1475-2859