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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Rational engineering of Kluyveromyces marxianus to create a chassis for the production of aromatic products

Fig. 1

Shikimate and phenylalanine/tyrosine biosynthesis in Kluyveromyces marxianus. The enzymes are named according to their orthologues in S. cerevisiae. In our study, genes for enzymes coloured red have been deleted or otherwise inactivated and those coloured green are overexpressed, with feedback-resistant alleles represented by the superscript fbr. Red dashed lines indicate product inhibition on enzymes, while dashed arrows indicated multiple reactions between the metabolites indicated. Abbreviations: PEP: phosphoenolpyruvate, E4P: erythrose 4-phosphate, DAHP: 3-deoxy-D-arabinoheptulosonate-7-phosphate, DHQ: 3-dehydroquinate, 3-DHS: 3-dehydroshikimate, SHIK: shikimic acid, S3P: shikimate-3-phosphate EPSP: 5-enoylpyruvateshikimate-3-phosphate, CHOR: chorismate, PPH; prephentate, (H)PPY: (hydroxyl)phenylpyruvate, 2-PE: 2-phenylethanol; PAA: phenylacetic acid; TYROSOL: tyrosol/para-hydroxyphenylethanol; PHPA: para-hydroxphenylacetate; TRP: tryptophan; TYR: tyrosine, PHE: phenylalanine

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Microbial Cell Factories

ISSN: 1475-2859

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