Fig. 7From: Inducible intracellular membranes: molecular aspects and emerging applicationsUPR phospholipid sensor. Ire1 is able to detect the presence of misfolded proteins or alterations of phospholipid composition in the membrane of the ER and is activated by dimerization and autophosphorylation. This activation leads to an unconventional splicing of HAC1 mRNA and the translation of Hac1, which activates gene expression and phospholipid biosynthesisBack to article page