Fig. 8

TAK-242 treatment modulated gut microbiota composition at the phylum level in DSS-induced UC mice. a Relative abundance of gut microbiota at the phylum level in each group. b Relative abundance of gut microbiota at the genera level in each group. c Linear discriminant analysis (LDA) score in each group. d Cladogram of gut microbiota in each group. Compared with the abundance in the normal group, the abundance of Proteobacteria in DSS-induced mice was markedly higher but was significantly decreased in the TAK-242 groups. Cyanobacteria and Epsilonbacteraeota were significantly increased in the DSS-induced colitis mice, but were obviously decreased after treatment with TAK-242 and 5-ASA. Interestingly, TAK-242 and 5-ASA significantly enhanced the relative abundance of Verrucomicrobia, which was not detectable in the guts of control and DSS-colitis mice. A: Control group, B: DSS group, C: DSS + 3 mg/kg TAK-242 group, D: DSS + 10 mg/kg TAK-242 group, E: DSS + 5-ASA group