Fig. 7

TAK-242 treatment modulated gut microbiota structure in DSS-induced UC mice. a Rarefaction curves of all samples. b Venn diagram indicating the differential numbers of OTUs in each group. c Alpha diversity in each group, as determined by abundance index (Chao1 and ACE) and diversity index (Shannon and Simpson). The alpha diversity index of the fecal microbiota showed significant differences among the groups (p < 0.05). d Analysis of similarities (ANOSIM) revealed that the differences in the gut microbiota community structure between groups were greater than those within each group. e Multiple samples principal component analysis (PCA) in each group. f Multiple sample principal coordinate analysis (PCoA) in each group. PCA and PCoA revealed that the gut microbiota in DSS-induced colitis significantly deviated from that observed in the control group. Treatment with TAK-242 markedly improved the distance but did not return the level to the level of the control group. A: Control group, B: DSS group, C: DSS + 3 mg/kg TAK-242 group, D: DSS + 10 mg/kg TAK-242 group, E: DSS + 5-ASA group