Fig. 2

Macroscopic and histopathological assessment of TAK-242 in DSS-induced colitis. a Morphology assessment of colon dissection. b HE staining of colon sections in each group (400 ×). c Macroscopic score of colonic damage in each group. d Microscopic score of colonic damage in each group. The data are expressed as the means ± SEM. Compared with the control group, the colonic mucosal lesions in the DSS group were obvious, with a wide range of hyperemia, edema, ulcers and bleeding observed (*p < 0.05, **p < 0.01, ***p < 0.001). Compared with the DSS-induced colitis group, with the treatment of TAK-242, the degree of colonic mucosal lesions was significantly ameliorated ( ^#p < 0.05, ^##p < 0.01, ^###p < 0.001)