Exploiting bacterial outer membrane vesicles as a cross-protective vaccine candidate against avian pathogenic Escherichia coli (APEC)

Hu, Rujiu; Li, Jing; Zhao, Yuezhen; Lin, Hua; Liang, Liu; Wang, Mimi; Liu, Haojing; Min, Yuna; Gao, Yupeng; Yang, Mingming

doi:10.1186/s12934-020-01372-7

Table 1 Top 20 most abundant proteins identified in MOMVs

From: Exploiting bacterial outer membrane vesicles as a cross-protective vaccine candidate against avian pathogenic Escherichia coli (APEC)

Rank	Protein accession	Gene name	Protein annotation	Subcellular localization	Biological function	MW (kDa)	Intensity
1	P0A910	ompA	Outer membrane protein A	Outer membrane	Cell wall/membrane/envelope biogenesis	37.2	7.57E+11
2	P69776	lpp	Major outer membrane prolipoprotein Lpp	Outer membrane	Cell wall/membrane/envelope biogenesis	8.3234	6.39E+11
3	P06996	ompC	Outer membrane protein C	Outer membrane	Cell wall/membrane/envelope biogenesis	40.368	4.83E+11
4	P0A903	bamC	Outer membrane protein assembly factor BamC	Outer membrane	Cell wall/membrane/envelope biogenesis	36.842	3.39E+11
5	P0A6F5	groL	60 kDa chaperonin	Cytoplasmic	Posttranslational modification, protein turnover, chaperones	57.328	3.07E+11
6	P0A905	slyB	Outer membrane lipoprotein SlyB	Outer membrane	Cell wall/membrane/envelope biogenesis	15.601	1.87E+11
7	P0A917	ompX	Outer membrane protein X	Outer membrane	Cell wall/membrane/envelope biogenesis	18.602	9.60E+10
8	P0A908	mipA	MltA-interacting protein	Outer membrane	Cell wall/membrane/envelope biogenesis	27.831	8.14E+10
9	P61320	lolB	Outer-membrane lipoprotein LolB	Outer membrane	Cell wall/membrane/envelope biogenesis	23.55	6.45E+10
10	P0A915	ompW	Outer membrane protein W	Outer membrane	Cell wall/membrane/envelope biogenesis	22.928	5.63E+09
11	P06959	aceF	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Cytoplasmic	Energy production and conversion	66.095	5.45E+09
12	P09394	glpQ	Glycerophosphodiester phosphodiesterase	Periplasmic	Energy production and conversion	40.843	4.41E+09
13	P13036	fecA	Fe (3 +) dicitrate transport protein FecA	Outer membrane	Inorganic ion transport and metabolism	85.321	4.02E+09
14	P0A940	bamA	Outer membrane protein assembly factor BamA	Outer membrane	Cell wall/membrane/envelope biogenesis	90.552	2.09E+09
15	P31554	lptD	LPS-assembly protein LptD	Outer membrane	Cell wall/membrane/envelope biogenesis	89.67	9.78E+08
16	P06971	fhuA	Ferrichrome outer membrane transporter/phage receptor	Outer membrane	Inorganic ion transport and metabolism	82.181	7.20E+08
17	P21420	nmpC	Putative outer membrane porin protein NmpC	Outer membrane	Cell wall/membrane/envelope biogenesis	40.302	7.03E+08
18	P0AFG8	aceE	Pyruvate dehydrogenase E1 component	Cytoplasmic	Energy production and conversion	99.667	6.63E+08
19	P21513	rne	Ribonuclease E	Cytoplasmic	Translation, ribosomal structure and biogenesis	118.2	6.48E+08
20	P00968	carB	Carbamoyl-phosphate synthase subunit beta	Periplasmic	Membrane biogenesis/synthesize carbamoyl phosphate	117.842	4.28E+08

MOMVs represents multi-serogroup outer membrane vesicles derived from avian pathogenic Escherichia coli

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ISSN: 1475-2859

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