Skip to main content

Table 1 Functions of gene products from cosAR7

From: Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

Gene

aa

Proposed function

Similar protein (acc. number)

Identical aa (%)

mtmZ

260

Putative thioesterase

WP_164185915.1

84

mtmA

460

Methylenetetrahydrofolate reductase

WP_043385055.1

83

mtmH

482

Adenosylhomocysteinase

WP_164185914.1

94

mtmD

355

Glucose-1P thymidylyltransferase

WP_164189839.1

88

mtmE

331

dTDP-glucose 4,6-dehydratase

WP_164189984.1

91

mtmTII

253

Ketoreductase

WP_164189846.1

90

mtmOII

531

Oxygenase

WP_078655152.1

84

mtmOIII

99

Monooxygenase

WP_164189850.1

87

mtmL

514

Acyl-CoA ligase

WP_051703560.1

80

mtmQ

315

Aromatase

WP_164189988.1

89

mtmX

150

Putative cyclase

WP_030997656.1

81

mtmP

422

beta-ketoacyl-(ACP) synthase

WP_030997655.1

93

mtmK

408

Ketosynthase chain-length factor

WP_164189853.1

88

mtmS

85

Acyl carrier protein

WP_164189855.1

82

mtmTI

254

Ketoreductase 

WP_164189991.1

86

mtmOI

436

FAD-binding monooxygenase 

WP_164189993.1

86

mtmY

257

Cyclase

WP_164189857.1

91

mtmTIII

247

Ketoreductase

WP_164189858.1

89

mtmC

420

D-mycarose 3-C-methyltransferase

WP_164189995.1

91

mtmU

328

D-oliose 4-ketoreductase

WP_030997647.1

80

mtmV

486

NDP-hexose 2,3-dehydratase

WP_164189860.1

84

mtmW

326

Aldo/keto reductase

WP_164189862.1

89

mtmGIV

407

Glycosyltransferase

WP_164189864.1

89