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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Disruption or reduced expression of the orotidine-5′-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger

Fig. 6

Intracellular metabolite profiling of the A. niger D353 and pyrG mutant D353.8. Intracellular metabolite profiling of the intermediates involved in central metabolism (a) and pyrimidine biosynthesis pathway (b). The relative level of each metabolite in A. niger D353.8 was calculated by dividing its normalized peak area by that of the control D353. Red arrows represent the relative quantitative change of the metabolite increase in A. niger D353.8, while green arrows represent the relative quantitative change of the metabolite decrease. The number next to the arrow represented the fold change of each intracellular metabolite in A. niger D353.8 against the ones in D353. OMP orotidine 5′-phosphate, UMP uridine monophosphate, UDP uridine biphosphate, UTP uridine triphosphate

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Microbial Cell Factories

ISSN: 1475-2859

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