Fig. 5

T2D showed altered microbial metabolome: Metabolomic reconstruction using humaN2 pipeline was performed to determine the microbial metabolome. Venn diagram representing enriched metabolites in C1 vs D1 (a). A partial least squares-discriminant analysis (PLS-DA) plot shows distinct clustering of the overall pathway composition within the two groups, implying major differences between the metabolic profiles of the two groups (b). A Variable Importance in Projection (VIP) analysis on the first principle component of PLS-DA plot identifying 22 named pathways significantly changing between C1 and D1 (c). Enrichment of metabolic groups in control and T2D groups visualized by pie charts (d). Venn diagram showing altered metabolites in C4 vs D4 (e). Distinct enrichment of bacteria that metabolize anti-oxidants in the D4 which was absent in C4 observed in parts-of-whole analysis (f). An enrichment of almost all the general metabolic pathways was observed in D4 when compared to D1 (g)