Fig. 4From: Engineering probiotics as living diagnostics and therapeutics for improving human healthEngineering probiotic E. coli strain for the detection of gut inflammation via a thiosulfate sensor. The presence of thiosulfate initiates the phosphorylation of thiosulfate response regulator ThsR and sensor ThsS, which activates the transcription of promoter PphsA. Over-expression of a fluorescent reporter gene under control of the promoter PphsA, the engineered probiotic E. coli strain harboring thiosulfate sensor demonstrated specific response and fluorescence in colon inflammation mouse modelBack to article page