Table 2 List of differentially regulated non-lmb genes in the lmbU deletion strain compared to original strain
Gene_id | Readcount | log2 fold change | p value | Description | ID/SM (%) | Origin (protein accession number) | EC number | |
|---|---|---|---|---|---|---|---|---|
SyBE2901 | SyBE2904 | |||||||
SLCG_3526 | 67.75 | 3879.47 | 5.84 | 2.28E−05 | 4-Hydroxyphenylpyruvate dioxygenase | 94/98 | Streptomyces olindensis, KDN74316.1 | 1.13.11.27 |
Transmembrane transporters (group 1) | ||||||||
 SLCG_3493 | 2228.6 | 402.1 | − 2.47 | 0.0045383 | MFS transporter, NarK/NasA family nitrate transporter | 93/95 | Streptomyces canus, KUN59611.1 |  |
 SLCG_6997 | 1262.37 | 68.17 | − 4.21 | 0.0004083 | MFS transporter, oxalate:formate antiporter family transporter | 94/98 | Streptomyces indicus, SDJ51645.1 |  |
 SLCG_7561 | 190.68 | 19.78 | − 3.27 | 0.001436 | MFS transporter, drug:H+ antiporter-2 (DHA2) family efflux transporter | 71/81 | Streptomyces sp. ST1015, WP_112483955.1 |  |
 SLCG_0089 | 26.2 | 0.81 | − 5.01 | 0.0031263 | Sugar ABC transporter substrate-binding protein | 97/99 | Streptomyces mirabilis, WP_052067725.1 |  |
 SLCG_7139 | 1957.42 | 146.97 | − 3.74 | 0.0009585 | ABC transporter permease | 88/92 | Streptomyces africanus, WP_086562194 |  |
 SLCG_7140 | 11211.76 | 501.86 | − 4.48 | 5.38E−05 | ATPase components of drug ABC transporters with duplicated ATPase domains | 90/95 | Streptomyces caeruleatus, KUO05737.1 |  |
 SLCG_7316 | 494.96 | 36.96 | − 3.74 | 0.00036306 | ABC-C family, MdlB, ATPase components of ABC-type multidrug transport system, | 93/96 | Streptomyces resistomycificus, KOG34263 |  |
 SLCG_1725 | 35.05 | 1.26 | − 4.79 | 0.0045114 | Drug/metabolite transporter (DMT) superfamily protein, threonine/homoserine efflux transporter RhtA | 86/90 | Streptomyces sp. MMG1533, KOU59304.1 |  |
Oxidoreductase (group 2) | ||||||||
 SLCG_3218 | 352.14 | 20.68 | − 4.09 | 0.0010757 | NADPH-dependent FMN reductase, predicted flavoprotein | 79/84 | Streptomyces viridochromogenes, ELS54031.1 |  |
 SLCG_7376 | 1426.23 | 113.98 | − 3.65 | 0.00025948 | Succinate dehydrogenase cytochrome b subunit | 95/97 | Streptomyces variegatus, KJK34840.1 |  |
 SLCG_2976 | 475.18 | 25.3 | − 4.23 | 0.00050136 | oxidoreductase, zinc-binding dehydrogenase, possible enoyl reductase | 85/90 | Streptomyces sp. Go-475, AXE86817.1 | 1.6.5.5 |
 SLCG_6211 | 743.9 | 18.18 | − 5.35 | 0.00050014 | Antibiotic biosynthesis monooxygenase | 84/90 | Streptomyces viridochromogenes, KMS69930.1 |  |
 SLCG_7612 | 883.35 | 32.55 | − 4.76 | 8.28E−05 | SgcJ/EcaC family oxidoreductase, nuclear transport factor 2 (NTF2-like) superfamily | 88/93 | Streptomyces aureocirculatus, WP_107055010.1 |  |
Cellular metabolic enzyme (group 3) | ||||||||
 SLCG_0221 | 3436.88 | 103.23 | − 5.06 | 1.44E−06 | Carbonic anhydrase | 92/97 | Streptomyces sp. NEAU-C151, TLS40487.1 | 4.2.1.1 |
 SLCG_1534 | 246.75 | 24.12 | − 3.35 | 0.0019877 | Epimerase | 90/92 | Streptomyces fulvoviolaceus, WP_030610101.1 |  |
 SLCG_6998 | 2683.63 | 242.47 | − 3.47 | 0.0028291 | Acetyl-CoA synthetase | 95/97 | Streptomyces indicus, SDJ51622.1 | 6.2.1.13 |
 SLCG_7000 | 1580.04 | 228.61 | − 2.79 | 0.0060806 | IlvB, acetolactate synthase large subunit | 99/99 | Streptomyces sp. NL15-2K, GCB44424.1 | 2.2.1.6 |
Hypothetical protein (group 4) | ||||||||
 SLCG_0224 | 1575.31 | 135.29 | − 3.54 | 0.0016004 | Hypothetical protein | 85/93 | Streptomyces sp. NL15-2K, WP_124439655.1 |  |
 SLCG_1709 | 40.05 | 3.17 | − 3.66 | 0.0048838 | Hypothetical protein | 85/92 | Streptomyces sp. HGB0020, EPD63200.1 |  |