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Table 1 Intrinsic yields (Yi/X) and maintenance coefficients (mi/X) from biomass growth obtained from chemostat cultivations

From: Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage

  Single-copy clone Multi-copy clone
YS/X (gMeOH g −1X ) 2.16 ± 0.08 2.21 ± 0.05
ms (gMeOH g −1X h−1) 0.014 ± 0.005 0.007 ± 0.004
\(Y_{{CO_{2} /X}}\) (\({\text{mol}}_{{{\text{CO}}_{2} }}\) C-mol −1X ) 0.95 ± 0.07 1.00 ± 0.05
\(m_{{CO_{2} }}\) (\({\text{mol}}_{{{\text{CO}}_{2} }}\) C-mol −1X  h−1) 0.012 ± 0.005 0.007 ± 0.003
\(Y_{{O_{2} /X}}\) (\({\text{mol}}_{{{\text{O}}_{2} }}\) C-mol −1X ) 1.92 ± 0.11 1.99 ± 0.07
\(m_{{O_{2} }}\) (\({\text{mol}}_{{{\text{O}}_{2} }}\) C-mol −1X h−1) 0.018 ± 0.007 0.010 ± 0.005
  1. ± Indicates standard error (SE) from regression analysis