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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin

Fig. 1

Metabolic engineering of the central carbon metabolism of C. glutamicum for increased malonyl-CoA availability and noreugenin synthesis. ACC: acetyl-CoA carboxylase; CS: citrate synthase; FAS: fatty acid synthase; FasR: transcriptional repressor of accBC, accD1, fasIA and fasIB, all involved in fatty acid synthesis; IolR: transcriptional repressor of genes involved in myo-inositol catabolism; IolT1: glucose/myo-inositol permease; PCS: pentaketide chromone synthase; PDHC: pyruvate dehydrogenase complex; PYC: pyruvate carboxylase; TCA: tricarboxylic acid cycle, Eliminated enzymatic reactions (black) or regulatory circuits (red): crossed out; reduced enzyme/pathway activity: grey

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Microbial Cell Factories

ISSN: 1475-2859

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