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Table 1 Study design and sampling

From: Saccharomyces cerevisiae morphological changes and cytokinesis arrest elicited by hypoxia during scale-up for production of therapeutic recombinant proteins

Scale (L)

Number of batches per DO set point

Dissolved oxygen (DO)

Set point (%)

EFTs of samples

(h)

10,000 L

(n = 3)

25.0

46.5, 54.0, 64.5, 76.5, 82.0

10 L

(n = 3)

12.5

46.5, 54.0, 63.5, 76.0, 81.5

8.5

5.0

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Microbial Cell Factories

ISSN: 1475-2859

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