Fig. 7

Pathway diagram of phosphorylated nucleosides which are key intermediates in glycosylation and cell wall synthesis pathways generating chitin, glucans, and poly-mannosylated (mannoproteins) proteins. Pathway of N-acetyl-glucosamine (GlcNAc) synthesis in cytoplasm from glycolysis, followed by formation of UPD-N-acetyl-glucosamine (UDP-GlcNAc) and its polymerization at the plasma membrane complex (green) to form chitin which is translocated into the periplasmic space. The glucans are synthesized from UDP-glucose in the cytoplasm by polymerization at the plasma membrane to form β-1,3- (blue) and β-1,6-glucan (red), and secreted into the periplasmic space. Poly-mannosylated proteins are processed through the endoplasmic reticulum and Golgi for packing in vesicles that are transported to the plasma membrane to be secreted into the periplasmic space