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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Saccharomyces cerevisiae morphological changes and cytokinesis arrest elicited by hypoxia during scale-up for production of therapeutic recombinant proteins

Fig. 6

Overlay of cell AR distributions at the end of 10 L and 10 KL bioreactor runs at three different DO set points. Significant differences in distributions attributed to scale and DO levels, are indicated by the arrows and correspond to two main populations with approximate AR values of 0.54 and 0.85. Difference in abundance of populations with ~ 0.5 AR is highlighted in the top panel and respective morphologies of representative cells are shown in the bottom panel. Average AR and ESD values of displayed cells are 0.54 and 7.02 µm respectively. Difference in abundance of populations with ~ 0.9 AR is highlighted in the top panel and respective morphologies of representative cells are shown in the bottom panel. Average AR and ESD values of displayed cells are 0.85 and 5.58 µm respectively

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Microbial Cell Factories

ISSN: 1475-2859

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