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Fig. 5 | Microbial Cell Factories

Fig. 5

From: A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation

Fig. 5

Chromatograms depicting bioconversion of pro chiral ketones. HPLC analysis of whole-cell transformed Crizotinib ketone intermediate (a) and the chiral separation of its alcohol (b). Similarly, whole-cell transformed dolastatin ketone intermediate (c) and the chiral separation of its alcohol (d). 1: alcohol product, 2: substrate, D: DMSO, S: (S)–isomer and R: (R)–isomer. In both the cases, the (S)–isomer production is > 90%

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Microbial Cell Factories

ISSN: 1475-2859

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