Fig. 4

Disruption of Acatg8 significantly increases cephalosporin C production of A. chrysogenum. a Cephalosporin C production of WT, ∆Acatg8 and Acatg8C was detected during fermentation in the modified MDFA medium. b Biomass of WT, ∆Acatg8 and Acatg8C during fermentation. The fungal mycelium dry weight was determined after drying at 42 °C in a hot air oven until a constant weight. After 72 h fermentation, the mycelium dry weight of ∆Acatg8 dropped quickly. Error bars show standard deviations of three independent experiments