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Table 2 Top-five along with additional validated (if any) transcriptional regulator targets identified by h-BeReTa for overproducing various compounds in C. glutamicum

From: In silico model-guided identification of transcriptional regulator targets for efficient strain design

Product

Nature of target

TRs

Glutamate

Upregulation

sigA, glxR, ramA, farR, argR [72]

Downregulation

cg1861, sigH, lexA, sugR, sigB, lldR [73]

Lycopene

Upregulation

sigH [49], relA, nrdR, ramB, ltbR

Downregulation

sugR, sigB [49], ripA, cg2544, znr

  1. TRs are provided in decreasing absolute gTRE trends. TR targets highlighted in italic letters are true positives (TP) and those underlined are false positives (FP)
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Microbial Cell Factories

ISSN: 1475-2859

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