Fig. 2From: In silico model-guided identification of transcriptional regulator targets for efficient strain designTR-hierarchy inferred from the E. coli regulatory network. Thirteen levels of TR–TR regulation were decoded from the TRN obtained from RegulonDB. Note that the self-regulating and loop forming TR–TR interactions are excluded from the TR-hierarchy to prevent gTREs from receiving unrealistically high valuesBack to article page