Fig. 4

Functional annotation of the global secretome. The inner circle indicates the proportion of annotated and non-annotated proteins in the global secretome. The middle circle shows the distribution of different types of signal peptides across the annotated and non-annotated portions of the global secretome, with a focus on signal peptide percentages within the different COG categories: Sec (dark grey), Sec-type Type I SPase signal peptide; Lipo (light grey), Lipoprotein Type II SPase signal peptide; TAT (black), Twin-arginine type signal peptide; ∆Sig (white), no signal peptide. The outer circle shows the distribution of annotated proteins across the different COG categories: C (energy production and conversion); E (amino acid transport and metabolism); G (carbohydrate transport and metabolism); K (transcription); L (replication/recombination and repair); M (cell wall/membrane/envelope biogenesis); N (cell motility); O (post-translational modification/protein turnover/chaperones); P (Inorganic ion transport and metabolism); Q (secondary metabolites biosynthesis, transport, and catabolism); S (function unknown); V (defence mechanisms)