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Table 3 Inhibition effects of compounds 1–14 on H1N1 virus multiplication in vitro

From: Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Compounds

IC50 (μM)a

CC50 (μM)b

1–10

> 200

> 1500

11

112.7

2196.8

12

26.9

1565.5

13

106.7

1623.9

14

28.8

1451.7

Ribavirin

112.9

1517.5

  1. The inhibition effects on influenza virus A/PR8/34 (H1N1) (MOI = 1.0) multiplication in MDCK cells were evaluated by virus yield reduction assay
  2. aInhibition concentration 50% (IC50): concentration required to inhibit influenza virus A/PR8/34 (H1N1) yield at 48 h post-infection by 50%. Values are mean ± SD (n = 4)
  3. bCytotoxic concentration 50% (CC50): concentration required to reduce MDCK cell viability by 50%. Values are mean ± SD (n = 3)
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Microbial Cell Factories

ISSN: 1475-2859

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