Skip to main content

Advertisement

Table 3 Inhibition effects of compounds 114 on H1N1 virus multiplication in vitro

From: Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Compounds IC50 (μM)a CC50 (μM)b
110 > 200 > 1500
11 112.7 2196.8
12 26.9 1565.5
13 106.7 1623.9
14 28.8 1451.7
Ribavirin 112.9 1517.5
  1. The inhibition effects on influenza virus A/PR8/34 (H1N1) (MOI = 1.0) multiplication in MDCK cells were evaluated by virus yield reduction assay
  2. aInhibition concentration 50% (IC50): concentration required to inhibit influenza virus A/PR8/34 (H1N1) yield at 48 h post-infection by 50%. Values are mean ± SD (n = 4)
  3. bCytotoxic concentration 50% (CC50): concentration required to reduce MDCK cell viability by 50%. Values are mean ± SD (n = 3)