Fig. 4
Schematic view of the putative role of PitA deficiency in the cellular Pi/PPi balance and histidine biosynthetic pathway. ATP adenosine triphosphate, PP i inorganic pyrophosphate, P i inorganic orthophosphate, Me2+-P i metal phosphate complexes, PRPP phosphoribosyl pyrophosphate, PR-ATP phosphoribosyl-ATP, PR-AMP phosphoribosyl-adenosine monophosphate, ADP adenosine diphosphate, L-His l-histidine, HisGE271K feedback-resistant ATP-phosphoribosyltransferase, HisI phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase, Ppa inorganic pyrophosphatase, PitA low affinity Pi transport system, PstSCAB phosphate specific transport system