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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface display

Fig. 2

Structural depictions of the alternative scaffold proteins discussed in the scope of this review. Structures were prepared from pdb identifiers 1IGT (IgG), 4GHK (vNAR), 5HDO (VHH), 3G3B (Variable Lymphocyte Receptor), ITTG (fibronectin domain III), 1SSO (Sso7d), 1HA9 (oMCoTI-II; knottin), 2XEE (DARPin), 1HPK (kringle domain), 2WNM (Gp2) and 1ILW (pyrazinamidase) using UCSF Chimera [133]. The proportions of the depicted scaffold proteins are relative and do not reflect the actual differences in size. Secondary structures are colored in red (helices) and blue (β-strands). Distinct hypervariable loops discussed in the scope of vNAR and VHH scaffolds are annotated

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Microbial Cell Factories

ISSN: 1475-2859

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