|
MDS42
|
24 (3.5)
|
168 (24.2)
|
336 (48.5)
|
504 (72.7)
|
|
cyc
R
|
2.99·10−7
|
7.07·10−7
|
2.27·10−5
|
3.04·10−5
|
|
rif
R
|
2.31·10−7
|
1.67·10−5
|
− 9.21·10−6*
|
1.51·10−6
|
|
Total
|
5.30·10−7
|
1.74·10−5
|
1.35·10−5
|
3.19·10−5
|
|
MG1655
|
24 (3.5)
|
168 (24.2)
|
336 (48.5)
|
504 (72.7)
|
|
cyc
R
|
1.03·10−7
|
6.30·10−7
|
2.97·10−6
|
4.34·10−4
|
|
rif
R
|
2.72·10−7
|
2.36·10−7
|
− 6.52·10−8*
|
5.99·10−4
|
|
Total
|
3.76·10−7
|
8.66·10−7
|
2.91·10−6
|
1.03·10−3
|
|
Fold diff. MDS42:MG1655
|
1.41
|
20.05
|
4.63
|
0.03
|
- Mutation rates for each strain (italics) were estimated separately at each locus, and then as a total. The time at which each sample was quantified is indicated in hours (italics) at the top of each column, with the number of generations, a scaled measure of time, indicated in the brackets below. The term ‘fold diff.’ refers to the ratio of the total mutation rate for MDS42 to MG1655 (μMDS42/μMG1655). The asterisks mark two negative mutation rate estimates. This occurred because rifR mutant colony counts for each strain during one out of three chemostat runs were slightly lower at 336 h compared to at 168 h, which produced a negative value
