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Table 3 Comparison of the bioprocesses associated with (R)-3,5-BTPE production via 3,5-BTAP reduction

From: Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol

Enzyme/strain

Substrate concentration (mM)

Production concentration (g/L)

Yield (%)

Time (h)

ee (%)

Reference

Ketoreductase P1B2 from Codexis

586

145.50

97

24

>99.9 (R)

[16]

ChKRED20 from Chryseobacterium sp.CA49

586

139.168

92

24

>99.9 (R)

[29]

Mutant LXCAR-S154Y from Leifsonia xyli HS0904

1000

212.965

82.5

12

>99.9 (R)

[41]

Mutant LXCAR-S154Y in ionic liquid

1000

252.7

98.7

12

>99.9 (R)

[22]

LkCR from Lactobacillus kefir fused with GDH

1191

297.27

96.7

10

>99.9 (R)

This study