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Fig. 6 | Microbial Cell Factories

Fig. 6

From: New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

Fig. 6

Characterization of genes encoding acyltransferases. UPLC chromatograms, monitored at 244 nm, of S. albus J1074 mutant strains altered in paulomycins biosynthesis by inactivation of acyltransferase coding genes plm3 (SAM5315), plm19 (SAM5331) and plm22 (SAM5334). Extracts were generated by culturing mutant strains in R5A liquid medium during 96 h. Labeled peaks correspond to paulomycin A (1), paulomycin B (2), paulomenol A (4), paulomenol B (5), 2-aminobenzoic acid (anthranilic acid) (8), compound not characterized (9*), N-acetyl-orto-aminobenzoic acid (10), deoxydehydrochorismic acid (11), paulomycin F (12), antimycic acid (13), 13-O-deacetyl-paulomycin E (14), 13-O-deacetyl-paulomycin B (15) and 13-O-deacetyl-paulomycin A (16)

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Microbial Cell Factories

ISSN: 1475-2859

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