Skip to main content
Fig. 7 | Microbial Cell Factories

Fig. 7

From: Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

Fig. 7

Characterization of genes involved in the biosynthesis of the PM100117 and PM100118 naphthoquinone unit. Analysis of PM100117 (1) and PM100118 (2) production by UPLC at 254 nm (a) and 216 nm (b) in Streptomyces caniferus GUA-06-05-006A wild type (GUA) and ΔgonM4, ΔgonMT, ΔgonSL, ΔgonS1, ΔgonS2, and gonP8 − mutant strains. Peaks with an absorption spectrum compatible with PM100117 and PM100118 derivatives lacking the NQ moiety are tagged with triangles. c Chemical structures of PM100118 derivatives lacking the naphthoquinone moiety. Asterisks indicate the point where the PM100118 chemical structures have been modified

Back to article page

Microbial Cell Factories

ISSN: 1475-2859

Contact us