Microbial Cell Factories

Table 1 MS and selection of ¹H and ¹³C-NMR data of compounds X, Y, Z and filipin III

From: Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives

Compound	MS	¹H and ¹³C-NMR position
Compound	MS	26	1′
X (1′-hydroxyfilipin I)	[M+Na]⁺ 661.6	δ_H: 2.24 and 2.29 δ_C: 37.94	δ_H: 3.72 δ_C: 70.47
Y (filipin I)	[M+Na]⁺ 645.5	δ_H: 2.25 and 2.35 δ_C: 37.89	δ_H: 1.44 and 1.68 δ_C : 29.47
Z (filipin II)	[M+Na]⁺ 661.5	δ_H: 3.93 δ_C: 72.11	δ_H: 1.43 and 1.68 δ_C: 29.60
Filipin III	[M+H]⁺ 655.4	δ_H: 3.94 δ_C: 73.00	δ_H: 3.66 δ_C: 69.50

Only the chemical shifts of the most relevant signals are listed. Positions are labelled according to their number in the polyketide backbone (Fig. 6).

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ISSN: 1475-2859

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