Figure 1

pH-responsive genes of T. reesei. A, Venn diagram showing the number of differentially expressed genes in comparison of the Δpac1 strain and its parental strain QM9414 at pH 6, as well the number of genes up-regulated in low pH conditions or in high pH conditions. (The number of genes with a significant difference in expression, p value < 0.01 and fold change log2 > 0.4, detected at both time points of the triplicate cultures). B, Functional classification of the genes with differential expression in different pH conditions. Classification is based on Eukaryotic orthologous groups. Glycoside hydrolase, carbohydrate esterase and polysaccharide lyase genes were annotated according to [30]. The genes that are up-regulated at high pH are designated as “High pH up-regulated”, and the genes up-regulated at low pH are designated as “Low pH up-regulated”.