Table 1 SNPs identified in mutants PM01 and PM02 as compared to the wild-type reference strain S. lividans 66
From: A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories
Genomic variants detected in PM01 | ||||||
|---|---|---|---|---|---|---|
Postion | Refence | Variant | codonChange | Sli GN | Sco GN | Description |
1188051 | C | T | Gly344Asp | SLI_1181 | SCO0948 | Alpha-mannosidase |
2924224 | G | A | Ala104Thr | SLI_2849* | SCO2513 | Putative DNA-binding protein |
3429004 | G | - | Leu165fs | SLI_3306a* | SCO2963 | Putative membrane protein |
3586487 | C | T | C16T | SLI_10025 | bldA | tRNA-Leu |
3717404 | C | T | Val70lle | SLI_3556 | SCO3202 | RNA polymerase sigma factor |
4336711 | - | C | Gly121fs | SLI_4122 | SCO3868 | Uncharacterized protein |
4499627 | C | G | Ala83Pro | SLI_4277 | SCO4043 | Uncharacterized protein |
4568325 | G | A | Pro119leu | SLI_4341 | SCO4111 | tRNA (guanine-N(7)-)-methyltransferase |
4967084 | A | - | Leu130fs | SLI_4756 | SCO4477 | Transcriptional regulator, MerR family |
5479836 | A | CC | Ala67fs | SLI_5273* | SCO4998 | DNA-binding protein |
5700075 | - | A | Val30Asp | SLI_5478 | SCO5200 | Putative membrane |
6362450 | A | G | Thr271Ala | SLI_6089* | SCO5821 | Putative serine proteinase |
6513051 | C | T | Pro142Leu | SLI_6232* | SCO5952 | Uncharacterized protein |
6750912 | G | C | Ala27Pro | SLI_6469* | SCO6076 | Putative dipeptidase |
7560900 | A | C | Thr484Ala | SLI_7172 | SCO6968 | Long-chain-fatty acid--CoA ligase |
Additional genomic variants detected in PM02 | ||||||
3537971 | G | A | VAl496lle | SLI_3391* | SCO3043 | Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr |
6420301 | G | C | Ala652Pro | SLI_6143* | SCO5871 | Osmosensitive K+ channel histidine kinase KdpD |