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Figure 1 | Microbial Cell Factories

Figure 1

From: A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale

Figure 1

Scheme of the CYP11B1-catalyzed 11 β-hydroxylation of 11-deoxycortisol yielding cortisol. Electrons are transferred from NADPH via AdR and Adx to CYP11B1, which activates molecular oxygen and incorporates one oxygen atom into the steroid substrate by means of a hydroxylation in a regio- and stereoselective manner, while the other oxygen is reduced to water.

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Microbial Cell Factories

ISSN: 1475-2859

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