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Figure 6 | Microbial Cell Factories

Figure 6

From: High-temperature cultivation of recombinant Pichia pastorisincreases endoplasmic reticulum stress and decreases production of human interleukin-10

Figure 6

Model of decreased rhIL-10 production due to high-temperature cultivation. High-temperature cultivation of an rhIL-10 expression strain leads to the prolonged accumulation of immature G3-pro-rhIL10 in ER, thus increasing the level of ER stress. Increased ER stress then disrupts the ER folding capacity by activating ER-phagy and increases yeast cell death.

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Microbial Cell Factories

ISSN: 1475-2859

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