Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness

Dijkstra, Annereinou R; Alkema, Wynand; Starrenburg, Marjo JC; Hugenholtz, Jeroen; van Hijum, Sacha AFT; Bron, Peter A

doi:10.1186/s12934-014-0148-6

Table 2 Gene expressions correlating with robustness

From: Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness

A
Locus tag	Gene	Function	Correlation
*llmg_1775*	cysK	O-acetylserine sulfhydrylase	Positive
*llmg_1776*	metC	Cystathionine gamma-synthase/cystathionine beta-lyase	Positive
llmg_0091	cysD	O-acetylhomoserine sulfhydrylase	Positive
llmg_1150		Hypothetical protein	Negative
*llmg_1494*		ABC transporter permease	Positive
llmg_0488		Multiple sugar-binding protein precursor	Positive
llmg_1718	uvrC	Excinuclease ABC subunit C	Positive
*llmg_1094*		Hypothetical protein	Positive
llmg_0199	feoB	Ferrous iron transport protein B-like protein	Positive
llmg_1388		Hypothetical protein	Negative
llmg_1042	trpA	Tryptophan synthase subunit alpha	Positive
llmg_0346	fhuC	Ferrichrome ABC transporter fhuC	Positive
llmg_0883		Hypothetical protein	Positive
llmg_1503		Surface protein	Negative
llmg_1662	uspA	Universal stress protein A	Positive
llmg_0428	fni	Isopentenyl pyrophosphate isomerase	Positive
*llmg_1985*	pepO2	Putative neutral endopeptidase O2	Negative
llmg_1275	aldB	AldB protein	Negative
B
Locus tag	Gene	Function	Correlation
llmg_1447		Hypothetical protein	Positive
llmg_0085		ABC transporter ATP-binding protein	Positive
llmg_1770	noxC	NADH oxidase	Positive
llmg_1641	butA	Acetoin reductase	Positive
llmg_0339	dar	Acetoin(diacetyl)reductase	Positive
llmg_2448	pgi	Glucose-6-phosphate isomerase	Negative
*llmg_1094*		Hypothetical protein	Positive
llmg_0003	rexB	ATP-dependent nuclease subunit B	Positive
llmg_0885	proB	Gamma-glutamyl kinase	Positive
llmg_0557	prfA	Peptide chain release factor 1	Positive
*llmg_1775*	cysK	O-acetylserine sulfhydrylase	Positive
llmg_0519	tig	Trigger factor	Negative
llmg_0960		Beta-glucosidase	Positive
llmg_0402	pbp1B	Penicillin-binding protein 1B	Positive
llmg_0755		Hypothetical protein	Positive
llmg_0959		Beta-glucosidase	Positive
llmg_1928	kinG	Sensor histidine kinase	Positive
llmg_1095		Hypothetical protein	Positive
*llmg_1494*		ABC transporter permease	Positive
llmg_1051		Transcription regulator	Negative
*llmg_1776*	metC	Cystathionine gamma-synthase/cystathionine beta-lyase	Positive
llmg_0485		Hypothetical protein	Positive
llmg_0592		Hypothetical protein	Positive
llmg_1317		N-acetylmannosamine-6-phosphate 2-epimerase	Positive
llmg_0403	pepA	glutamyl-aminopeptidase	Negative
llmg_1957		ABC transporter, ATP-binding protein	Negative
llmg_1093		Putative secreted protein	Positive
llmg_2047		Universal stress protein E	Negative
llmg_0556		Hypothetical protein	Positive
llmg_0909	kinA	Sensor protein kinase kinA	Negative
llmg_1642	butB	2,3-butanediol dehydrogenase	Positive
llmg_0870		Transporter	Negative
llmg_1181	ilvE	Branched-chain amino acid aminotransferase	Negative
llmg_1830	menX	Menaquinone biosynthesis related protein	Positive
llmg_0487		Putative trehalose/maltose hydrolase	Positive
llmg_0066	araT	Aromatic amino acid aminotransferase	Negative
llmg_1961	tenA	Transcriptional activator TenA	Negative
llmg_1387		Hypothetical protein	Negative
llmg_1091		Putative secreted protein	Positive
llmg_1582		Hypothetical protein	Negative
llmg_0722	serS	Seryl-tRNA synthetase	Negative
*llmg_1985*	pepO2	Putative neutral endopeptidase O2	Negative
llmg_0205		Hypothetical protein	Negative
llmg_2035	gidA	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA	Positive
llmg_1098	glpD	GlpD protein	Positive
llmg_1638	mleS	Malate dehydrogenase	Positive
llmg_1128		Hypothetical protein	Positive
llmg_0908	llrA	Two-component system regulator llrA	Negative
llmg_0760		Putative transglycosylase	Positive
llmg_2039		Ribonuclease III	Positive
llmg_0383	ppnK	Inorganic polyphosphate/ATP-NAD kinase	Positive
llmg_1096		Hypothetical protein	Positive
llmg_1090		Hypothetical protein	Positive
llmg_1031	trpG	Anthranilate synthase component II	Positive

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ISSN: 1475-2859

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