Maximum oxygen transfer capacity (OTR
) and k
a-values versus the filling volume. for the chemical 0.5 mM sulfite system, the E. coli fermentation in WR medium and the Hansenula polymorpha fermentation in SYN6-MES medium. The method from Hermann et al. [9, 10] was applied for the determination and calculation of OTRmax and kLa-values for the sulfite system. The OTRmax and kLa-values for the fermentations were calculated by applying the proportionality factor (f) from table 1 on the OTRmax-values of the sulfite system. Operation conditions (Sulfite system/E. coli/H. polymorpha): various filling volumes between 100-260 μL, at 25°C/30°C/30°C temperature, 995 rpm shaking frequency and 3 mm shaking diameter.