Microbial production host selection for converting second-generation feedstocks into bioproducts

Table 3 Resistance of the microorganisms studied to inhibitors present in feedstock hydrolysates

Production host	Furfural	HMF	Acetate	NaCl	MgSO₄	Growth at pH4
E. coli	1	2	5	40	80	-
C. glutamicum	0.5	2	10	40	> 80	-
S. cerevisiae Bioscreen*	1	1	5	20	> 80	+/-
S. cerevisiae Micro-Oxymax*	n.d.	1	n.d.	20	n.d.	n.d.
P. stipitis	1	2	5	40	> 80	+/-
T. reesei	1	5	20	100	> 80	+
A. niger	1	5	20	100	> 80	+

The concentration (g/l) of the inhibitor is shown at which inhibition results in <50% of the growth rate/CO₂ production rate without inhibitor.
*In order to check correlation of the methods, S. cerevisiae was evaluated using both the Bioscreen and Micro-Oxymax method (see Methods).
n.d. = not determined
+ good growth
+/- moderate growth
- no or very slow growth

ISSN: 1475-2859