Figure 2From: Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenesBiosythetic pathway of nucleoside moiety of nikkomycin in S. ansochromogenes. Some biosynthetic steps were omitted. SanO, L-His-specific didomain NRPS; SanP, type II thioesterase; SanQ, heme hdyroxylase; SanR, uracil phosphoribosyltransferase; SanS, enolpyruvyl transferase; Upp, uracilmphosphoribosyltransferase; PRPP, 5-phosphoribosyl-alpha-1-diphosphate; PEP, phosphoenolpyruvate;. Disruption of sanP resulted in blocking the synthesis of β-OH-His.Back to article page