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Figure 2 | Microbial Cell Factories

Figure 2

From: Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

Figure 2

Biosythetic pathway of nucleoside moiety of nikkomycin in S. ansochromogenes. Some biosynthetic steps were omitted. SanO, L-His-specific didomain NRPS; SanP, type II thioesterase; SanQ, heme hdyroxylase; SanR, uracil phosphoribosyltransferase; SanS, enolpyruvyl transferase; Upp, uracilmphosphoribosyltransferase; PRPP, 5-phosphoribosyl-alpha-1-diphosphate; PEP, phosphoenolpyruvate;. Disruption of sanP resulted in blocking the synthesis of β-OH-His.

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