Figure 4From: Medical bioremediation of age-related diseasesAdvanced glycation end-products. Two of the most abundant AGEs are glucosepane and carboxymethyl lysine. AGE modification of long-lived proteins contributes to extracellular matrix dysfunction, leading to an array of conditions related to aging and diabetes. These include atherosclerosis, amyloidosis, cataracts, retinopathy, neuropathy, nephropathy, and impaired wound healing.Back to article page